LABORATORY OF ELECTROMYOGRAPHY - RESEARCH ACTIVITIES
The Laboratory, besides clinical work, is actively engaged in research on the most important neuromuscular diseases in adulthood, including:
Mononeuropathies, Polyneuropathies, Myopathies, Myasthenia Gravis, Myasthenic Syndrome, Motor Neuron Disease - Amyotrophic Lateral Sclerosis.
Research projects in progress:
1. Normal (reference) values of jitter in the muscles: Orbicularis Oculi, Frontalis, Extensor Digitorum, Tibialis Anterior
2. Assessment of jitter sensitivity between (a) Orbicularis Oculi and Frontalis, (β) Extensor Digitorum and Tibialis Anterior.
3. Carpal Tunnel Syndrome (CTS): Correlation of symptoms with Sensory Nerve Conduction assessment findings (area, time to peak, total duration)
4. Correlation of Sensory Nerve Conduction Velocity of Sural nerve with Vibration sense measurement
5. Study of End-plate potentials
Doctoral theses in progress
1. P. Koutsoudaki: “Usage of Transcranial Magnetic Stimulation to study cortical excitability in ethanol-dependent persons during therapeutic detoxification”
Representative publications
1. Zambelis T, Piperos P, Karandreas N. Fibrillation potentials in paraspinal muscles in chronic lumbosacral radiculopathy. Acta Neurol Scand.2002; 105: 314-317.
2. Zambelis T, Karandreas N, Tzavellas E, Kokotis P, Liappas J. Large and small fiber neuropathy in chronic alcohol-dependent subjects. J Peripher Nerv Syst. 2005 Dec;10(4):375-81.
3. Manta P, Mamali I, Zambelis T, Aquaviva T, Kararizou E, Kalfakis N. Immunocytochemical study of cytoskeletal proteins in centronuclear myopathies.Acta Histochem. 2006;108(4):271-276.
4. Karandreas N, Papadopoulou M, Kokotis P, Papapostolou A, Tsivgoulis G, Zambelis T. Impaired interhemispheric inhibition in amyotrophic lateral sclerosis.Amyotroph Lateral Scler. 2007 Apr;8(2):112-118.
5. Spengos K, Vassilopoulou S, Papadimas G, Tsivgoulis G, Karandreas N, Zambelis T, Manta P. Dropped head syndrome as prominent clinical feature in MuSK-positive Myasthenia Gravis with thymus hyperplasia. Neuromuscul Disord. 2008 Feb;18(2):175-177.
6. Zambelis T, Panas M, Kokotis P, Karadima G, Kararizou E, Karandreas N. Central motor and sensory pathway involvement in an X-linked Charcot-Marie-Tooth family.Acta Neurol Belg. 2008 Jun;108(2):44-47.
7. Zambelis T, Tsivgoulis G, Karandreas N.. Carpal tunnel syndrome: associations between risk factors and laterality. Eur Neurol. 2010;63(1):43-47. Epub 2009 Dec 23.
8. Papadopoulou M, Chairopoulos K, Anagnostou E, Kokotis P, Zambelis T, Karandreas N. Concurrent bilateral projection and activation of motor cortices in a patient with congenital mirror movements: a TMS study. Clin Neurol Neurosurg. 2010 Nov; 112(9):824-828.
9. Zambelis T, Kokotis P, Karandreas N. Repetitive nerve stimulation of facial and hypothenar muscles: relative sensitivity in different myasthenia gravis subgroups.Eur Neurol. 2011; 65(4):203-207. Epub 2011 Mar 17.
10. Bakola E, Kokotis P, Zambelis T, Karandreas N. Inappropriate surgeries in Amyotrophic Lateral Sclerosis: a still considerable issue. Amyotroph lateral Scler and Frontotemporal degener 2014; 15: 315-17
11. Zambelis T, Papadakis G, Chatzipanagiotou S, Michalopoulou M, Kokotis P, Karandreas N. Diabetic Neuropathy: Comparison between Bangladeshi immigrants and Greek-born subjects. J Periph Nervous System .2014;19: 307-310
12. Th. Zambelis, V. Pappas, P. Kokotis, V. Zouvelou, N. Karandreas.. Patients with ocular symptoms referred for electrodiagnosis. How many of them suffer from Myasthenia Gravis?Acta Neurol Belg 2015; 115: 671-674.
13. Zis P, Zis V, Xirou S, kemenetzoglou E, Zambelis T, Karandreas N. Rapid screening for carpal tunnel syndrome: A novel method and comparison with established others.J Clin Neurophysiol 2015; 32(4): 375-379
14. Bougea A, Zambelis T, Voskou P, Katsika PZ, Tzavara C, Kokotis P, Karandreas N. Reliability and validation of the greek version of the Boston Carpal Tunnel Questionnaire. Hand (N Y). 2017 Aug 1:1558944717725379.
15. Thomas Zambelis, Pinelopi Koutsoudaki, Evangelos Anagnostou , Panagiotis Kokotis , Nikolaos Karandreas. Electromyographic study of Thoracic Paraspinal and Rectus abdominis muscles in ALS. J Clin Neurophysiol 2018; 35: 267-269
16. George K. Papadimas, George P. Paraskevas, Thomas Zambelis, Chrisostomos Karagiaouris, maria Bourbouli, Anastasia Bougea, Maggie C. Walterb, Nicolas U. Schumacherb, Sabine Krauseb, Elisabeth Kapaki. The multifaceted clinical presentation of VCP-proteinopathy in a Greek family. Acta Myologica 2017; XXXVI: p. 1-4