MARIA ANAGNOSTOULI
Assistant Professor in Neurology
Demyelinating Diseases Unit &
Director of Immunogenetics Laboratory,
1st Department of Neurology, Medical School,
National and Kapodistrian University of Athens,
Aeginition Hospital, Vas. Sofias Ave 72-74, Athens, Greece
E-mail: managnost@med.uoa.gr
Telephone: +302107289278
Maria Anagnostouli studied at the Athens Medical School and completed her specialty in Neurology at the 1st Neurological Clinic of the National and Kapodistrian University of Athens (NKUA). Since the beginning of her specialty she has been involved in research protocols of the Clinical Research Laboratory, focusing on neuroimmunology and serological typing of Human Leucocyte Antigens (HLA), which have been associated with an increased risk of developing autoimmune diseases and especially with Multiple Sclerosis (MS), the reference disease for all of her clinical and research activity. She completed her doctoral thesis on the determination of vitamin biotin, in serum and CSF in neurological patients, in collaboration with the Department of Immunopeptide Chemistry of the Research Center "DEMOKRITOS", whose conclusions were recently used for the MS therapeutics, as originally proposed by her. In 1998, after years of training in Athens tissue histocompatibility centers, her participation as a member of the European Federation of Immunogenetics (EFI) and her participation in the World Molecular HLA Workshop, at Professor Terasaki's Lab in Los Angeles she organized and operated autonomously the Research Immunogenetics Laboratory, in the Aeginition Hospital. For over ten years she has collaborated with doctoral candidates and postgraduate students who have either completed or advanced their doctoral theses on molecular HLA genotyping in distinguished and rare forms of MS, like familial MS, pediatric MS,tumefactive MS, NMOSD, periodontitis and other dental problems in patients with MS etc. For many years the HLA system has been also being studied in the Immunogenetics Laboratory and in common neurodegenerative diseases such as Alzheimer's disease, Parkinson and Amyotrophic Lateral Sclerosis (ALS), but also other autoimmune neurological diseases such as myasthenia, GBS syndrome etc.
In 2011, She organized the first Panhellenic Conference dedicated solely to MS, in Greece, where she analyzed the value of the HLA system for the initiation and phenotypic characteristics of MS, but primarily for the decision making, regarding personalized treatment in the future. She has also organized 5 other conferences on Adult and Pediatric MS, neuroimmunology andimmunogenetics, as well as the first Workshop on Immunogenetics in Neurology, with prominent scientists in the Greek and Pan-European space, at the new site of the Laboratory of Immunogenetics of Aeginition Hospital.
PhD Students
1.Artemiadis Artemios (completed)
2.Aquaviva Teresa (completed)
3.Katsavos Serafeim (submitted 3rd progress part)
4.Gontika Maria (submitted 2nd progress part)
5.Skarlis Charalampos (submitted 1st progress part)
6.Markoglou Nikolaos (in the near future)
7.Simeakis George (submitted 1st progress part)
MSc Students
1.Manouseli Renia (completed)
2.Filippopoulou Constantina (completed)
3.Nita Erisa (completred)
4.Basi Margarita (completed)
5.Xatzinikolaou Charitomeni (completed)
6. Babili Ioanna (completed)
7. Varsami Athanasia (in completion)
8.Panagopoulou Zaxaroula (in completion)
Selected Publications-Original Articles, from the Immunogenetics Laboratory
HLA-DRB1 RISK OR PROTECTIVE ALLELE DIFFERENCES BETWEEN FAMILIAL AND SPORADIC MULTIPLE SCLEROSIS IN A HELLENIC COHORT Katsavos, Serafeim, Artemiadis, Artemios, Gontika Maria Skarlis Charalambos, Markoglou Nikolaos, Davaki Panagiota, Stamboulis Eleftherios, Kilindireas Konstantinos, Stefanis Leonidas, Anagnostouli Maria Postgrad Medicine, 131 (7), 490-495, Sep 2019
HLA-DRB1* alleles genotyping in chronic inflammatory demyelinating polyneuropathy in Greek patients. Anagnostouli MC, Acquaviva T, Artemiadis AK, Rentzos M, Karandreas N, Davaki P, Stamboulis E. J Peripher Nerv Syst. 2014 Jun;19(2):187-9. doi: 10.1111/jns5.12061.
HLA-DRB1 15:01 and Epstein-Barr virus in a multiple sclerosis patient with psoriasis, nasopharyngeal and breast cancers. Lessons for possible hidden links for autoimmunity and cancer. Anagnostouli M, Anagnostoulis G, Katsavos S, Panagiotou M, Kararizou E, Davaki P. J Neurol Sci. 2014 Apr 15;339(1-2):26-31. doi: 10.1016/j.jns.2014.02.003. Epub 2014 Feb 11.
Biomarkers in Multiple Sclerosis: An Up-to-Date Overview. Katsavos S, Anagnostouli M. Mult Scler Int. 2013;2013:340508. doi: 10.1155/2013/340508. Epub 2013 Jan 22.
Familial bipolar disorder and multiple sclerosis: a three-generation HLA family study. Bozikas VP, Anagnostouli MC, Petrikis P, Sitzoglou C, Phokas C, Tsakanikas C, Karavatos A. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):835-9.
Campylobacter jejuni O:19 serotype-associated Guillain-Barré syndrome in a child: the first case reported from Greece. Chatzipanagiotou S, Kilidireas K, Trimis G, Nicolaou C, Anagnostouli M, Athanassaki C, Giannoulia A, Legakis N, Youroukos S. Clin Microbiol Infect. 2003 Jan;9(1):69-72.
Reviews-Book Chapters
HLA Allele Frequencies in Pediatric and Adolescent Multiple Sclerosis Patients Maria Anagnostouli and Maria Gontika Open access peer-reviewed chapter Submitted: April 10th 2018 Reviewed: September 24th 2018Published: December 8th 2018 DOI: 10.5772/intechopen.81645
Anti-Myelin Oligodendrocyte Glycoprotein and Human Leukocyte Antigens as Markers in Pediatric and Adolescent Multiple Sclerosis: on Diagnosis, Clinical Phenotypes, and Therapeutic Responses. Gontika MP, Anagnostouli MC. Mult Scler Int. 2018 Nov 22;2018:8487471. doi: 10.1155/2018/8487471. eCollection 2018. Review.
HLA-Genotype in Multiple Sclerosis: The Role in Disease Onset, Clinical Course, Cognitive Status and Response to Treatment: A Clear Step Towards Personalized Therapeutics Stamatelos Petros and Maria Anagnostouli Immunogenet open access 2017, Vol 2(1): 116
Cerebrospinal Fluid Markers in Neuroinflammation: The Paradigm of Optic Neuritis Dimitrios P Besinis, Maria C Anagnostouli March 2017 Methods in Pharmacology and Toxicology DOI: 10.1007/978-1-4939-6843-5_14 In book: Histamine Receptors as Drug Targets
Human leukocyte antigens‑immunogenetics of neuromyelitis optica or Devic’s disease and the impact on the immunopathogenesis, diagnosis and treatment: a critical review Maria Panos Gontika, Maria Constantinos Anagnostouli Neuroimmunol Neuroinflammation 2014;1:44-50.10.4103/2347-8659.139713 Open Access Review